HIV/AIDS

Investigators at Chinese University of Hong Kong target HIV/AIDS

Published in AIDS Weekly, November 29th, 2010

2010 NOV 29 -- "From the seeds of Acacia confusa, a chitinase-like antifungal protein designated as acaconin that demonstrated antifungal activity toward Rhizoctonia solani with an IC50 of 30 +/- 4 mc M was isolated. Acaconin demonstrated an N-terminal sequence with pronounced similarity to chitinases and a molecular mass of 32 kDa," investigators in Hong Kong, People's Republic of China report.

"It was isolated by chromatography on Q-Sepharose, SP-Sepharose and Superdex 75 and was not bound by either ion exchanger. Acaconin was devoid of chitinase activity. The antifungal activity against Rhizoctonia solani was completely preserved from pH 4 to 10 and from...

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Source: AIDS Weekly (2010-11-29)

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