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HIV/AIDS Therapy

Findings from Radboud University Advance Knowledge in HIV/AIDS Therapy

Published in AIDS Weekly, January 24th, 2011

2011 JAN 24 -- According to a study from Netherlands, "Neurocognitive disorders due to human immunodeficiency virus type 1 (HIV-1) infection have been reported in 25-60% of cases,(1-3) despite a sustained viral response in peripheral blood while on highly active anti-retroviral therapy (HAART). A possible reason may be that the central nervous system (CNS) is less accessible for anti-retroviral agents, therefore this sanctuary site can provide a reservoir for ongoing HIV-1 replication."

"Mutations conferring resistance to anti-retroviral drugs may predominate in compartments where drug levels are suboptimal. This review provides an overview on the...

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