HIV/AIDS

Data on HIV/AIDS Described by Researchers at University of Siena

Published in AIDS Weekly, March 28th, 2011

2011 MAR 28 -- Researchers detail in 'The CXCL12/CXCR4 axis as a therapeutic target in cancer and HIV-1 infection,' new data in HIV/AIDS. "The seven-spanning transmembrane G-protein coupled receptor CXCR4, which specifically binds to the chemokine CXCL12, is expressed on many cell types, including various types of tumor cells. CXCR4 plays a crucial role in organ-specific metastasis, directing migration of malignant cells expressing this receptor toward microenvironments where the cognate ligand is secreted," investigators in report.

"CXCL12 has a direct growth and survival-promoting effect for various cancer cells and enhances moreover tumor angiogenesis by...

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Source: AIDS Weekly (2011-03-28)

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