HIV/AIDS

Findings in HIV/AIDS Reported from H.S. Bodiwala and Co-Researchers

Published in AIDS Weekly, April 11th, 2011

2011 APR 11 -- According to a study from Maharashtra, India, "Designing multi-functional ligands is a recent strategy by which multiple targets can be inhibited by a single entity. A series of caffeoyl-anilide compounds based on structures of various integrase and CCR5 inhibitors have been designed and synthesized as anti-HIV agents in the present study."

"Most of the compounds exhibited potent anti-HIV activity at micromolar concentration in CEM-GFP CD4+ T cells infected with HIV-1NL4.3 virus. Compound 14 showed a lower EC50 and better TI as compared to AZT. Mechanism based studies suggest that these compounds inhibit either one or in some cases, both the...

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Source: AIDS Weekly (2011-04-11)

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