Enzyme Inhibitors

Data on Enzyme Inhibitors Detailed by Researchers at Nagoya City University

Published in AIDS Weekly, May 30th, 2011

2011 MAY 30 -- According to recent research from Aichi, Japan, "Pharmacological manipulations to purge human immunodeficiency virus (HIV) from latent reservoirs have been considered as an adjuvant therapeutic approach to highly-active antiretroviral therapy for the eradication of HIV. Our novel histone deacetylase inhibitor NCH-51 induced expression of latent HIV-1 with minimal cytotoxicity."

"Using chromatin immunoprecipitation assays, we observed a reduction of HDAC1 occupancy, histone hyperacetylation and the recruitment of positive transcription factors at the HIV-1 promoter in latently infected-cells under the treatment with NCH-51. Mutation studies of...

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Source: AIDS Weekly (2011-05-30)

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