HIV/AIDS
Case Western Reserve University Publishes Research in HIV/AIDS
Published in AIDS Weekly, July 18th, 2011
2011 JUL 18 -- According to the authors of a study from Cleveland, Ohio, "The RNA response element TAR plays a critical role in HIV replication by providing a binding site for the recruitment of the viral transactivator protein Tat. Using a structure-guided approach, we have developed a series of conformationally-constrained cyclic peptides that act as structural mimics of the Tat RNA binding region and block Tat-TAR interactions at nanomolar concentrations in vitro."
"Here we show that these compounds block Tat-dependent transcription in cell-free systems and in cell-based reporter assays. The compounds are also cell permeable, have low toxicity, and...
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Source: AIDS Weekly (2011-07-18)
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