HIV/AIDS
Findings from D.R. Burton and Co-Authors Broaden Understanding of HIV/AIDS
Published in AIDS Weekly, August 1st, 2011
2011 AUG 1 -- According to the authors of a study from La Jolla, California, "To guide vaccine design, we assessed whether human monoclonal antibodies (MAbs) b12 and b6 against the CD4 binding site (CD4bs) on HIV-1 gp120 and F240 against an immundominant epitope on gp41 could prevent vaginal transmission of simian HIV (SHIV)-162P4 to macaques. The two anti-gp120 MAbs have similar monomeric gp120-binding properties, measured in vitro, but b12 is strongly neutralizing and b6 is not. F240 is nonneutralizing."
"Applied vaginally at a high dose, the strongly neutralizing MAb b12 provided sterilizing immunity in seven of seven animals, b6 in zero of five animals,...
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Source: AIDS Weekly (2011-08-01)
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