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New HIV/AIDS Research from Texas Tech University Described

Published in AIDS Weekly, September 5th, 2011

2011 SEP 5 -- "Inspired by the anti-human immunodeficiency virus (HIV) activity of analogues of beta-galactosylceramide (GalCer), a set of mono- and di-saccharide fatty acid esters were designed as GalCer mimetics and their binding to the V3 loop peptide of HIV-1 and anti-HIV activity evaluated. 1,1-linked Gal-Man and Glu-Man disaccharides with an ester on the Man subunit bound the V3 loop peptide and inhibited HIV infectivity in single round infection assays with the TZM-bl cell line," researchers in El Paso, Texas report.

"IC50's were in the 50 mc M range with no toxicity to the cells at concentrations up to 200 mc M. These compounds appear to inhibit...

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