HIV/AIDS
Data from New York Blood Center Advance Knowledge in HIV/AIDS
Published in AIDS Weekly, November 7th, 2011
2011 NOV 7 -- According to the authors of recent research published in the journal Chemmedchem, "Exploration of potent inhibitors of the HIV-1 gp41 fusion core formation is a promising strategy to discover small-molecule HIV-1 entry inhibitors for the treatment of HIV-1 infection. In this paper, a series of novel betulinic acid-polyphenol conjugates was designed, guided by molecular modeling of the binding of betulinic acid (BA) and phenolic galloyl/caffeoyl groups in the groove on the gp41 N-terminal heptad repeat (NHR) trimeric coiled coil."
"These conjugates were synthesized via conjugation of galloyl and caffeoyl groups with BA at the C-28...
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Source: AIDS Weekly (2011-11-07)
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