HIV/AIDS

Investigators from Michigan State University Target HIV/AIDS

Published in AIDS Weekly, December 12th, 2011

2011 DEC 12 -- According to the authors of recent research published in the journal Biochemistry, "Human immunodeficiency virus (HIV) infection of a host cell begins with fusion of the HIV and host cell membranes and is mediated by the gp41 protein, a single-pass integral membrane protein of HIV. The 175 N-terminal residues make up the ectodomain that lies outside the virus."

"This work describes the production and characterization of an ectodomain construct containing the 154 N-terminal gp41 residues, including the fusion peptide (FP) that binds to target cell membranes. The Fgp41 sequence was derived from one of the African clade A strains of HIV-1...

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Source: AIDS Weekly (2011-12-12)

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