HIV/AIDS
Data from Baylor University College of Medicine Advance Knowledge in HIV/AIDS
Published in AIDS Weekly, March 26th, 2012
2012 MAR 26 -- "The replication of integrated human immunodeficiency virus type 1 (HIV-1) is dependent on the cellular cofactor cyclin T1, which binds the viral Tat protein and activates the RNA polymerase II transcription of the integrated provirus. The activation of resting CD4(+) T cells upregulates cyclin T1 protein levels independently of an increase in cyclin T1 mRNA levels, suggesting a translational repression of cyclin T1 in resting CD4(+) T cells," scientists writing in the Journal of Virology report.
"Hypothesizing that microRNAs (miRNAs) repress cyclin T1 translation in resting CD4(+) T cells and that this inhibition is lifted upon cell...
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Source: AIDS Weekly (2012-03-26)
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