Deutsch Krebsforschungszentrum, Heidelberg
HDAC inhibitors trigger apoptosis in HPV+ cells by inducing E2F-p73 pathway
Published in Aging and Elder Health Week, September 5th, 2004
"Histone deacetylase (HDAC) inhibitors induce an intrinsic type of apoptosis in human papillomavirus (HPV)-positive cells by disrupting the mitochondrial transmembrane potential (DeltaPsim ).
"Loss of DeltaPsim was only detected in E7, but not in E6 oncogene-expressing cells. HDAC inhibition led to a time-dependent degradation of the pocket proteins pRb, p107 and p130, releasing 'free' E2F-1 following initial G1 arrest," investigators in Germany report.
"Inhibition of proteasomal proteolysis, but not of caspase activity, rescued...
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