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Health Canada
CNS genes involved in response to scrapie agents identified in mice
January 9th, 2005
Central nervous system genes involved in the host response to scrapie agents have been identified in a murine model. In a recent study from Canada, "cDNA microarrays were used to examine gene-expression profiles at early, middle (preclinical) and late (clinical) time points" after inoculation of mice with adapted scrapie agents. "A number of genes that showed significant changes in expression during the clinical stage of disease were identified," reported S. Booth and coauthors at Health Canada in Winnipeg. "Of these, 138 were upregulated and 20 were downregulated." "A smaller number of genes showed differential expression at the...
Source: Aging & Elder Health Week (2005-01-09)
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