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Cardiff University
Vector toxicity confounds herpes simplex virus-mediated gene delivery
January 9th, 2005
Vector toxicity confounds herpes simplex virus-mediated gene delivery. According to published research from Wales, "`herpes simplex virus (RSV)-derived vectors have been suggested for potential use in gene therapy for Parkinson disease (PD). HSV naturally infects adult neuronal cells and possesses a large genome for the insertion of transgenes." "In the present study, we have used two different HSV constructs to deliver glial cell line-derived neurotrophic factor (GDNF) to the striatum, and to assess the neuroprotective effects of the GDNF product in an intrastriatal 6-hydroxydopamine lesion model," C. Monville and colleagues, Cardiff University,...
Source: Aging & Elder Health Week (2005-01-09)
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