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Bernhard Nocht Inst. Tropical Medicine, Hamburg
Antiviral compounds against Lassa/SARS coronavirus/Ebola screened via RT-PCR
January 9th, 2005
Antiviral compounds against Lassa virus, SARS coronavirus and Ebola virus were screened via RT-PCR. According to published research from Germany, "This report describes the application of real-time PCR for testing antivirals against highly pathogenic viruses such as Lassa virus, SARS coronavirus and Ebola virus. The test combines classical cell culture with a quantitative real-time PCR read-out." "The assay for Lassa virus was validated with ribavirin, which showed an IC50 of 9 mcg/ml. Small-scale screening identified a class of imidazole nucleoside/nucleotide analogues with antiviral activity against Lassa virus," reported S. Gunther and...
Source: Aging & Elder Health Week (2005-01-09)
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