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INSERM U514, Reims
VEGF expression in lung neuroendocrine cell lesions might be linked to fibrosis
January 9th, 2005
VEGF expression in lung neuroendocrine cell lesions might be linked to fibrosis. "Pulmonary tumorlets and neuroendocrine (NE) cell hyperplasia are part of a continuous spectrum of NE-cell hyperplasia, going from NE hyperplasia to carcinoid. Vascular endothelial growth factor (VEGF) is a potent endothelial cell mitogen that has been shown to be increased in hypoxic lung. We hypothesized that tumorlets and NE-cell hyperplasia, which occur frequently in this context, were partly responsible for VEGF secretion," investigators in France report. "Immunohistochemical analysis of VEGF and both VEGF receptor 1 (VEGFR-1)and VEGFR-2 was performed on paraffin...
Source: Aging & Elder Health Week (2005-01-09)
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