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Aventis Pharma Deutschland GmbH
Molecular mechanisms of Ezetimibe elucidated
April 10th, 2005
The molecular mechanisms of the cholesterol-lowering agent Ezetimibe have been elucidated. "Intestinal cholesterol absorption is an important regulator of serum cholesterol levels," scientists in Germany explained. "Ezetimibe is a specific inhibitor of intestinal cholesterol absorption recently introduced into medical practice; its mechanism of action, however, is still unknown." "Ezetimibe neither influences the release of cholesterol from mixed micelles in the gut lumen nor the transfer of cholesterol to the enterocyte brush border membrane," noted W. Kramer and colleagues at Aventis Pharma Deutschland GmbH. Using "membrane-impermeable Ezetimibe...
Source: Aging & Elder Health Week (2005-04-10)
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