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GlaxoSmithKline Research & Development, Ltd.
Antibodies specific for myelin-associated glycoprotein are neuroprotective
April 10th, 2005
Antibodies specific for myelin-associated glycoprotein show promise for the treatment of stroke. "The inhibitory activity of myelin-associated glycoprotein (MAG) on neurons is thought to contribute to the lack of regenerative capacity of the CNS after injury. The interaction of MAG and its neuronal receptors mediates bidirectional signaling between neurons and oligodendrocytes. The novel finding that an anti-MAG monoclonal antibody not only possesses the ability to neutralize the inhibitory effect of MAG on neurons but also directly protects oligodendrocytes from glutamate-mediated oxidative stress-induced cell death is reported here," researchers in England...
Source: Aging & Elder Health Week (2005-04-10)
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