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Eli Lilly & Company
Cerebral hemorrhage dependent on antibody recognition of amyloid beta
April 10th, 2005
Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta. According to recent research from the United States, "Passive immunization with an antibody directed against the N terminus of amyloid beta (A-beta) has recently been reported to exacerbate cerebral amyloid angiopathy (CAA)-related microhemorrhage in a transgenic animal model. Although the mechanism responsible for the deleterious interaction is unclear, a direct binding event may be required. We characterized the binding properties of several monoclonal anti-A-beta...
Source: Aging & Elder Health Week (2005-04-10)
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