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Lady Davis Institute, Montreal
Tat methylation by PRMT6 regulates HIV-1 gene expression
April 10th, 2005
Tat methylation by PRMT6 regulates HIV-1 gene expression. According to recent research from Canada, "The human immunodeficiency virus (HIV) transactivator protein, Tat, stimulates transcription from the viral long terminal repeats via an arginine-rich transactivating domain. "Since arginines are often known to be methylated, we investigated whether HIV type 1 (HIV-1) Tat was a substrate for known protein arginine methyltransferases (PRMTs). Here we identify Tat as a substrate for the arginine methyltransferase, PRMT6." "Tat is specifically associated with and methylated by PRMT6 within cells. Overexpression of wild-type PRMT6, but...
Source: Aging & Elder Health Week (2005-04-10)
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