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Brown University
Inflammatory and antiviral responses in liver studied, requirements clarified
April 10th, 2005
According to a study from the United States, monocyte chemoattractant protein-1 and CCR2 interactions are required for IFN-alpha/beta-induced inflammatory responses and antiviral defense in the liver. "IFN-alpha/beta-mediated functions promote production of MIP-1alpha (or CCL3) by mediating the recruitment of MIP-1alpha-producing macrophages to the liver during early infection with murine CMV. These responses are essential for induction of NK cell inflammation and IFN-gamma delivery to support effective control of local infection. Nevertheless," wrote K.L. Hokeness and colleagues, Brown University, "it remains to be established if additional...
Source: Aging & Elder Health Week (2005-04-10)
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