M.D. Anderson Cancer Center
CD44+ prostate cancer cells are enriched in tumorigenic and metastatic progenitor cells
Published in Aging and Elder Health Week, May 14th, 2006
"CD44 is a multifunctional protein involved in cell adhesion and signaling. The role of CD44 in prostate cancer (PCa) development and progression is controversial with studies showing both tumor-promoting and tumor-inhibiting effects," investigators in the United States report.
According to L. Patrawala and colleagues at M.D. Anderson Cancer Center in Houston, "Most of these studies have used bulk-cultured PCa cells or PCa tissues to carry out correlative or overexpression experiments. The key experiment using prospectively purified cells has not been carried...
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