Stockholm University
Cancer susceptibility could be related to mitotic defects in XRCC3 variant T241M
Published in Aging and Elder Health Week, May 28th, 2006
"The XRCC3 variant T241M, but not D213N, has been reported to be associated with an increased risk of some cancers. XRCC3 is 1 out of 5 RAD51 paralogues and is involved in homologous recombination, as are the BRCA1 and BRCA2 proteins," investigators in Sweden reported.
"However, in contrast to mutations in BRCA1 and BRCA2, the XRCC3(T241M) protein is proficient in homologous recombination and reverts sensitivity to mitomycin C found in XRCC3-deficient cells, whereas XRCC3(D213N) is defective in homologous recombination. Here, we report that...
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