University of Western Australia
Hematopoietic transcription factor Scl critical for neuronal development
Published in Aging and Elder Health Week, June 4th, 2006
"The basic helix-loop-helix (bHLH) transcription factor Scl displays tissue-restricted expression and is critical for the establishment of the hematopoietic system; loss of Scl results in embryonic death due to absolute anemia.
"Scl is also expressed in neurons of the mouse diencephalon, mesencephalon and metencephalon; however, its requirement in those sites remains to be determined," wrote investigators in Australia.
According to C.K. Bradley and colleagues at the University of Western Australia in Subiaco, "Here we report conditional deletion of Scl in...
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