New York Medical College
Nuclear factor of activated T cells regulates tumor necrosis factor production
Published in Aging and Elder Health Week, June 4th, 2006
"Because NFAT has been implicated in TNF production as well as osmoregulation and salt and water homeostasis, we addressed whether CaR-mediated TNF production in medullary thick ascending limb (mTAL) cells was NFAT dependent," wrote H.I. Abdullah and colleagues, New York Medical College.
"TNF production in response to addition of extracellular Ca2+ (1.2 mM) was abolished in mTAL cells transiently transfected with a dominant-negative CaR construct (R796W) or...
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