Alzheimer Disease
Researchers from University of Paris provide details of new studies and findings in the area of Alzheimer disease
Published in Aging and Elder Health Week, May 11th, 2008
"It is known that 5-HT4 receptor agonists increase sAPPa levels in the cortex and hippocampus of mice as well as in a model of Alzheimer's disease (AD). As sAPP(x is thought to have pro-mnesic properties, we assessed whether its increase induces cognitive improvement in a spatial memory task and whether it reverses a scopolamine-induced memory deficit," scientists writing in the journal Behavioural Brain Research report.
"Mice treated or not treated with scopolamine were trained in the Morris water maze for 3 days. Before the probe test, they received an injection of either a 5-HT4 receptor agonist (prucalopride or RS 67333), or an acetylcholinesterase inhibitor...
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