Published in Angiogenesis Weekly, February 7th, 2000
Homing of hematopoietic stem cells to the bone marrow (BM) involves sequential interaction with adhesion molecules expressed on BM endothelium (BMEC) and chemokine stromal derived factor-1 (SDF-1). The mechanism whereby adhesion molecules regulate the SDF-1-induced transendothelial migration process, however, is not known.
E-selectin is an endothelial-specific selectin that is constitutively expressed by the BMEC in vivo. Thus, A. J. Naiyer and colleagues hypothesized that...
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