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Gastroenterology

Indigenous microbes regulate intestinal vascular modeling

Published in Angiogenesis Weekly, February 7th, 2003

Microbes that colonize the gastrointestinal tract are responsible for some aspects of neovascular remodeling in mice.

"The adult mouse intestine contains an intricate vascular network. The factors that control development of this network are poorly understood. Quantitative three-dimensional imaging studies revealed that a plexus of branched interconnected vessels developed in small intestinal villi during the period of postnatal development that coincides with assembly of a complex society of indigenous gut microorganisms (microbiota)," said United States investigators.

"To investigate the impact of this environmental transition on vascular...

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