Cancer Therapy
Anti-mouse VEGFR2 antibodies are useful for vascular targeting and imaging
Published in Angiogenesis Weekly, November 21st, 2003
"We generated a panel of eight rat IgG(2a) monoclonal antibodies with high affinity for mouse VEGFR2 (KDR/ Flk-1), the main receptor that mediates the angiogenic effect of VEGF-A. The antibodies (termed RAFL, Rat Anti Flk) bound to dividing endothelial cells more strongly than they did to nondividing cells. Most of the RAFL antibodies blocked 125I-VEGF(165) binding to VEGFR2," investigators in the United States reported.
"Three of eight antibodies localized to VEGFR2-positive tumor endothelium after intravenous injection into mice bearing orthotopic MDA-MB-231...
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Source: Angiogenesis Weekly (2003-11-21)
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