Enzymology
Hyaluronan-binding protease stops cytokine-driven endothelial cell growth
Published in Angiogenesis Weekly, June 4th, 2004
According to recent research from Germany, "recently we identified a plasma serine protease with a high affinity to glycosaminoglycans like heparin or hyaluronic acid, termed hyaluronan-binding protease (HABP). Since glycosaminoglycans are found on cell surfaces and in the extracellular matrix a physiological role of this plasma protease in a pericellular environment was postulated. Here we studied the influence of HABP on the regulation of endothelial cell growth.
"We found that HABP efficiently prevented the basic fibroblast growth factor/epidermal growth factor...
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Source: Angiogenesis Weekly (2004-06-04)
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