Neuroscience
Angiotensin II type 1 receptor blockade supports cerebral cortex angiogenesis
Published in Angiogenesis Weekly, March 3rd, 2006
"Angiotensin II is known to stimulate angiogenesis in the peripheral circulation through activation of the AT1 receptor. This study investigated the effect of angiotensin receptor blockade on cerebral cortical microvessel density," scientists in the United States report.
"Rats (6-7 wk old, n=5-17) were instrumented with femoral arterial and venous indwelling catheters for arterial blood pressure measurement and drug administration. Rats were treated for 3 or 14 days with the AT1 receptor blocker losartan (50 mg/day in drinking water) or vehicle. Brains were sectioned...
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Source: Angiogenesis Weekly (2006-03-03)
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