Drug Development
Sulfated steroid sokotrasterol boosts angiogenesis
Published in Angiogenesis Weekly, October 6th, 2006
"The potential to promote neovascularization in ischemic tissues using exogenous agents has become an exciting area of therapeutics. In an attempt to identify novel small molecules with angiogenesis promoting activity, we screened a library of natural products and identified a sulfated steroid, sokotrasterol sulfate, that induces angiogenesis in vitro and in vivo," scientists writing in the journal Circulation Research report.
"We show that sokotrasterol sulfate promotes endothelial sprouting in vitro, new blood vessel formation on the chick chorioallantoic membrane, and accelerates...
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Source: Angiogenesis Weekly (2006-10-06)
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