HIV/AIDS Pathogenesis
HIV-Tat upregulates multidrug resistance protein 1 expression in blood-brain barrier
Published in Angiogenesis Weekly, October 6th, 2006
According to recently published research from the United States, "Central nervous system (CNS) complications of human immunodeficiency virus (HIV) infection remain a serious health risk in HIV/acquired immunodeficiency syndrome despite significant advances in highly active antiretroviral therapy (HAART).
"Specific drugs used for HAART are substrates for the efflux transport systems, such as the multidrug resistance-associated proteins (MRPs), which are present on brain microvascular endothelial cells (BMEC) and astrocytes, that is, the main cell types that form...
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Source: Angiogenesis Weekly (2006-10-06)
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