Angiogenesis
Findings from University of California, Department of Pediatrics broaden understanding of angiogenesis in children
Published in Angiogenesis Weekly, October 26th, 2007
Researchers detail in 'Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastoma,' new data in angiogenesis. "'Targeted expression of MYCN to the neural crest [under control of the rat tyrosine hydroxylase (TH) promoter] causes neuroblastoma in transgenic mice (TH-MYCN) and is a well-established model for this disease. Because high levels of MYCN are associated with enhanced tumor angiogenesis and poor clinical outcome in neuroblastoma, we serially characterized malignant progression, angiogenesis, and sensitivity to angiogenic blockade in tumors from these animals," scientists writing in the journal Cancer Research report.
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Source: Angiogenesis Weekly (2007-10-26)
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