Fibrosarcoma

Research data from University of Wurzburg update understanding of fibrosarcoma

Published in Angiogenesis Weekly, March 14th, 2008

"Hypoxia-inducible factor-1 (HIF-1) overexpression has been linked to tumor progression and poor prognosis. We investigated whether targeting of HIF-1 using chetomin, a disrupter of the interaction of HIF-1 with the transcriptional coactivator p300, influences the radiosensitivity of hypoxic HT 1080 human fibrosarcoma cells," investigators in Wurzburg, Germany report.

"Optimal dose of chetomin was determined by EGFP-HRE gene reporter assay in stably transfected HT 1080 cells. Cells were assayed for expression of the hypoxia-inducible genes carbonic anhydrase 9 (CA9) and vascular endothelial growth factor ( VEGF) by RT-PCR and for clonogenic survival after irradiation...

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Source: Angiogenesis Weekly (2008-03-14)

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