Angiogenesis

Research conducted at Vanderbilt University has provided new information about angiogenesis

Published in Angiogenesis Weekly, November 7th, 2008

According to recent research from the United States, "Microvascular insufficiency represents a major cause of end-organ failure among diabetics. The current studies were undertaken to determine whether dysregulation of the angiopoietins/Tie-2 system would result in an impairment of smooth muscle cell (SMC) recruitment and vascular maturation, which contributes to impaired angiogenesis in diabetes."

"Tie-2 expression was significantly attenuated, whereas angiopoietin-2 (Ang-2) was increased in db/db mice subjected to myocardial ischemia. Our morphological analysis showed that the number of SMC coverage area per neovessel was significantly reduced in db/db mice. This was...

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Source: Angiogenesis Weekly (2008-11-07)

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