Vascular Endothelial Growth Factor

Study data from University of Texas update understanding of vascular endothelial growth factor

Published in Angiogenesis Weekly, June 5th, 2009

According to recent research from the United States, "Hypoxia and hypoxia inducible factor-1 alpha (HIF-1 alpha) play a critical role in glioblastoma (GBM) which is characterized by highly aggressive and widespread cell invasion into adjacent normal brain tissue. The purpose of this study wall to investigate the effect of the novel aminothiazole compound SNS-032 in glioblastoma cell invasion under hypoxic condition."

"SNS-032 is a potent and selective inhibitor of cyclin-dependent kinases 2, 7 and 9 and inhibits both cell cycle and transcription. We analyzed the effect of SNS-032 (0.5 mc M) on HIF-1 alpha expression and its major trans-regulating factors including...

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Source: Angiogenesis Weekly (2009-06-05)

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