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Angiogenesis Weekly

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Life Sciences



Recent studies from Duke University add new data to life sciences



June 19th, 2009

According to recent research from the United States, "Despite substantial evidence that nitric oxide (NO) and/or endogenous S-nitrosothiols (SNOs) exert protective effects in a variety of cardiovascular diseases, the molecular details are largely unknown. Here we show that following left coronary artery ligation, mice with a targeted deletion of the S-nitrosoglutathione reductase gene (GSNOR(-/-)) have reduced myocardial infarct size, preserved ventricular systolic and diastolic function, and maintained tissue oxygenation."

"These profound physiological effects are associated with increases in myocardial capillary density and S-nitrosylation of the transcription factor...


Source: Angiogenesis Weekly (2009-06-19)

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