Angiogenesis Weekly
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Prostate Cancer
Researchers from Keimyung University, Medical Department report recent findings in prostate cancer
June 19th, 2009
"Melatonin, the main secretory product of the pineal gland, has been shown to exert an oncostatic activity in cancer cells. Recently, several studies have shown that melatonin has antiangiogenic properties," scientists in South Korea report. "However, the mechanism by which melatonin exerts antiangiogenenic effects is not understood. Hypoxia inducible factor (HIF)-1 is a transcription factor which mediates adaptive response to changes in tissue oxygenation. HIF-1 is a heterodimer formed by the association of a constitutively expressed HIF-1 beta subunit and a HIF-1 alpha subunit, the expression of which is highly regulated. In this study, pharmacologic concentrations of...
Source: Angiogenesis Weekly (2009-06-19)
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