Angiogenesis Weekly
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Antibody Libraries
Research on antibody libraries detailed by H. Hu and co-authors
June 19th, 2009
According to a study from Beijing, People's Republic of China, "Angiogenesis is critical for cancer development and metastasis. Here we have employed a functional antibody library-based proteomic screen to identify proteins that participate in and might be used as therapeutic targets for tumor-related angiogenesis." "Mice were immunized with human esophageal cancer endothelial cells (HECEC). The antibody library was established with the mouse spleen cells the serum of which had most anti-angiogenic effect. Monoclonal antibodies were subjected to an immunoreactive and functional screen and monoclonal antibodies that reacted strongly with cell surface antigens of HECECs...
Source: Angiogenesis Weekly (2009-06-19)
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