Angiogenesis Weekly
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Angiogenesis
Reports summarize angiogenesis study results from Harvard University
November 6th, 2009
"Mechanical signals regulate blood vessel development in vivo, and have been demonstrated to regulate signal transduction of endothelial cell (EC) and smooth muscle cell (SMC) phenotype in vitro. However, it is unclear how the complex process of angiogenesis, which involves multiple cell types and growth factors that act in a spatiotemporally regulated manner, is triggered by a mechanical input," researchers in the United States report. "Here, we describe a mechanism for modulating vascular cells during sequential stages of an in vitro model of early angiogenesis by applying cyclic tensile strain. Cyclic strain of human umbilical vein (HUV) ECs up-regulated the...
Source: Angiogenesis Weekly (2009-11-06)
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