Angiogenesis Weekly
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Angiogenesis
Scientists at Medical University of Vienna discuss research in angiogenesis
November 6th, 2009
"VEGF-A is the major trigger of vasculogenesis and physiologic angiogenesis. We have investigated to which extent the gene repertoire induced by VEGF-A in endothelial cells is distinct from that of other growth factors and inflammatory cytokines," researchers in Vienna, Austria report. "Genes upregulated in human umbilical vein endothelial cells treated with VEGF, EGF or IL-I were compared by microarray analysis and clusters characteristic for individual or combinations of inducers were defined. VEGF-A upregulated in comparison to EGF a five-fold larger gene repertoire, which surprisingly overlapped to 60% with the inflammatory repertoire of IL-I. As shown by real-time...
Source: Angiogenesis Weekly (2009-11-06)
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