Angiogenesis Weekly
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Angiogenesis
Investigators at Manchester Metropolitan University release new data on angiogenesis
November 13th, 2009
"We used short-interfering RNA (siRNA) to knockdown the hyaluronan (HA) receptors CD44 and the receptor for hyaluronan-mediated motility (RHAMM) in vascular endothelial cells to investigate their role in angiogenesis. We showed that CD44 and RHAMM single knock-down inhibited low molecular weight hyaluronan (o-HA)-induced endothelial cell tube formation in Matrigel, but no change in the control, epidermal growth factor-induced tube formation was observed," investigators in Manchester, the United Kingdom report. "Using a Kinexus phosphoprotein array and confirmational Western blotting we were able to show a differential effect on HA-induced protein expression after CD44...
Source: Angiogenesis Weekly (2009-11-13)
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