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Anti-Infectives Week

Susan Hasty, Publisher

Table of Contents . . . December 29th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Anti-Infectives Week | Other Publications

Virology - A benzothiadiazine inhibitor blocks hepatitis C virus replicase function

Drug Development - Potent HIV "maturation inhibitor" developed

Food-borne Illness - High level of antibiotic resistance in bacteria that cause food poisoning

Malaria Therapy - Atovaquone/proguanil regimen safe and effective for young children

Orthopedic Infections - Polymethylmethacrylate beads can deliver antibiotics at the infection site

Acne Therapy - Madison Keats to assist in identifying a licensing partner for PCL-016

Alzheimer Disease - Alzheimer patients have some decreased cytokine responses as disease progresses

Anthrax - Antibodies may provide option to vaccines, antibiotics

Antibiotic Resistance - New weapon developed to combat resistant bacteria

Antibiotics - Triclosan: The next new drug?

Antiproliferative Agents - Neomycin inhibits activation of cyclin D1; is antiproliferative to glioma cells

Astrocyte Ischemia - Geldanamycin protects astrocytes from death, is involved in HSP70 up-regulation

Atopic Dermatitis - First phase II clinical trial of dermatology drug, NPI 32101, begins

Bacterium Detection - Finger-stick test for Helicobacter pylori now available

Breast Cancer - Breast cancer risk from antibiotics may be due to altered immunity, microflora

Burn Medicine - In aging model of burn injury, macrophage number is same, MCP-1 lower initially

Collaborations - Medicines for Malaria Venture, UNC-CH ink agreement to develop malaria drug

Cystic Fibrosis - Consensus is reached on identification, therapy for allergic aspergillosis in CF

Distribution Agreement - Biomedical company announces wound gel distribution agreement for Latin America

Drug Development -  P. falciparum iron superoxide inhibitors identified

Drug Development - HIV protease inhibitors based on bicyclic guanidinium subunit synthesized

Drug Development - Novel HIV gp120-binding RNA aptAm has potent neutralizing activity

Drug Development - Oils from Cameroon medicinal plants have potent antimalarial activity

Drug Development - Phenanthridine derivative strongly inhibits HIV Rev-RRE interaction

Drug Development - Safety and efficacy of tipranavir reviewed

Encephalitis - Two people survive Balamuthia amoebic encephalitis without recurrence

Escherichia Coli - Colicin E3 binds E. coli BtuB, is brought to OmpF for channel transport

Fever Induction - Pyrogens induce increases in hypothalamic beta-endorphins that trigger fever

Fungal Infections - Mycotic osteomyelitis by Scedosporium apiospermum tends to escape culture

Genital Tract Infections - Infections and other risk factors linked to premature birth, experts say

HIV Therapy - Combination, order of anti-HIV drugs make a difference in first-time recipients

HIV Transmission - Use of antivirals by HIV-infected people reduces ability to infect partners

HIV/AIDS - Liver transplantation feasible for HIV patients

HIV/AIDS Coinfection - HAART can resolve HCV infection in HIV patients

HIV/AIDS Gene Therapy - SV40 vectors delivering alpha(1)AT genes protect T-cells against HIV

HIV/AIDS Lipodystrophy - Autonomic neuropathy may underlie HIV-related fat redistribution

HIV/AIDS Lipodystrophy - Very-low-fat diets may be beneficial for HIV-LD patients

HIV/AIDS RNA Research - Antiviral mechanisms of HIV exonic splicing silencers clarified

HIV/AIDS Therapy - Enzyme-linked minisequence HIV drug-resistance screen accurate, cost-effective

HIV/AIDS Therapy - HAART induces tolerogenic HLA-G expression by peripheral monocytes

HIV/AIDS Therapy - HCV coinfection delays CD4 cell recovery after HAART initiation

HIV/AIDS Therapy - Levels of anti-p24 IgG1 may mark HAART efficacy

HIV/AIDS Therapy - Web-based pager system modestly improves antiretroviral treatment adherence

Haemophilus Ducreyi -  H. ducreyi cytolethal distending toxin can be blocked by CdtA-CdtC complex

Helicobacter Pylori - A complete H. pylori cag pathogenicity island confers greater disease

Helicobacter Pylori - Gastric mucosa reduces IL-4 when faced with Helicobacter pylori with cag

Immunology -  L. pneumophila acts on a protein kinase, stops macrophage IL-12 production

Immunology - Albumin has innate immunity function, inhibits B. dermatitidis yeast growth

Immunology - Monoclonal antibody protects against S. aureus infections

Infectious Disease -  H. ducreyi can give pustule or resolution regardless of phagocytosis level

Infectious Disease - Lyophilized S. cerevisiae responsible for ICU outbreak

Infectious Disease - Ocular toxoplasmosis can be treated to eliminate deterioration of vision

Influenza - Company reports positive laboratory-confirmed results from FluINsure vaccine

Kidney Disease - Understanding the role of complement in renal disease may lead to better therapy

Legionnaires Disease -  Legionella pneumophila LvhB2 is involved in infectivity efficiency at 30 degrees C

Malaria Therapy - Reintroduction of standard malaria treatment in Vietnam qualified success

Mergers and Acquisitions - Health products company obtains rights to antimicrobial line of products

Otorhinolaryngology - Allergies and autoimmune disease can affect the ears

Patents - Company announces new patent for nanobacteria eradication and therapeutics

Plague - ID Biomedical announces additional contract related to a subunit plague vaccine

Pulmonary Medicine - Cardiac troponin I positivity may help predict pediatric RSV respiratory failure

Pulmonary Tuberculosis - Cutaneous tuberculosis rare in treated pulmonary TB patients

Quality Assurance - Practice parameters are being developed for managing pediatric allergy, asthma

Rickettsias -  Anaplasma marginale varies membrane antigens; may explain disease cyclicity

Salmonella Enterica Typhi - Commensal bacterial products can increase invasion potential of S. enterica

Staphylococcus Aureus - Study: Battle MRSA bacteria in hospitals by flooding hospitals with viruses

Streptococcus Pneumoniae -  S. pneumoniae virulence involves control of oxygen by the MicAB kinase

Transplant Medicine -  Xylohypha bantiana can cause curable brain abscess similar to aspergillosis

Transplant Medicine - Polyomavirus nephropathy, tubulitis benefit most from lower immunosuppression

Tuberculosis Diagnostics - Colorimetric assay suitable for identification of drug-resistant TB strains

Tuberculosis Drug Resistance - High rate of fluoroquinolone resistance in new TB cases

Tuberculosis Drug Resistance - Mycobacterial katG, inhA mutations highly predictive of isoniazid resistance

Tuberculosis Therapy - Plasma pooling effective for finding rifampicin bioequivalence in FDCs

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