Susan Hasty, Publisher
Table of Contents . . . December 29th, 2003
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Anti-Infectives Week | Other Publications
Virology - A benzothiadiazine inhibitor blocks hepatitis C virus replicase function
Drug Development - Potent HIV "maturation inhibitor" developed
Food-borne Illness - High level of antibiotic resistance in bacteria that cause food poisoning
Malaria Therapy - Atovaquone/proguanil regimen safe and effective for young children
Orthopedic Infections - Polymethylmethacrylate beads can deliver antibiotics at the infection site
Acne Therapy - Madison Keats to assist in identifying a licensing partner for PCL-016
Alzheimer Disease - Alzheimer patients have some decreased cytokine responses as disease progresses
Anthrax - Antibodies may provide option to vaccines, antibiotics
Antibiotic Resistance - New weapon developed to combat resistant bacteria
Antibiotics - Triclosan: The next new drug?
Antiproliferative Agents - Neomycin inhibits activation of cyclin D1; is antiproliferative to glioma cells
Astrocyte Ischemia - Geldanamycin protects astrocytes from death, is involved in HSP70 up-regulation
Atopic Dermatitis - First phase II clinical trial of dermatology drug, NPI 32101, begins
Bacterium Detection - Finger-stick test for Helicobacter pylori now available
Breast Cancer - Breast cancer risk from antibiotics may be due to altered immunity, microflora
Burn Medicine - In aging model of burn injury, macrophage number is same, MCP-1 lower initially
Collaborations - Medicines for Malaria Venture, UNC-CH ink agreement to develop malaria drug
Cystic Fibrosis - Consensus is reached on identification, therapy for allergic aspergillosis in CF
Distribution Agreement - Biomedical company announces wound gel distribution agreement for Latin America
Drug Development - P. falciparum iron superoxide inhibitors identified
Drug Development - HIV protease inhibitors based on bicyclic guanidinium subunit synthesized
Drug Development - Novel HIV gp120-binding RNA aptAm has potent neutralizing activity
Drug Development - Oils from Cameroon medicinal plants have potent antimalarial activity
Drug Development - Phenanthridine derivative strongly inhibits HIV Rev-RRE interaction
Drug Development - Safety and efficacy of tipranavir reviewed
Encephalitis - Two people survive Balamuthia amoebic encephalitis without recurrence
Escherichia Coli - Colicin E3 binds E. coli BtuB, is brought to OmpF for channel transport
Fever Induction - Pyrogens induce increases in hypothalamic beta-endorphins that trigger fever
Fungal Infections - Mycotic osteomyelitis by Scedosporium apiospermum tends to escape culture
Genital Tract Infections - Infections and other risk factors linked to premature birth, experts say
HIV Therapy - Combination, order of anti-HIV drugs make a difference in first-time recipients
HIV Transmission - Use of antivirals by HIV-infected people reduces ability to infect partners
HIV/AIDS - Liver transplantation feasible for HIV patients
HIV/AIDS Coinfection - HAART can resolve HCV infection in HIV patients
HIV/AIDS Gene Therapy - SV40 vectors delivering alpha(1)AT genes protect T-cells against HIV
HIV/AIDS Lipodystrophy - Autonomic neuropathy may underlie HIV-related fat redistribution
HIV/AIDS Lipodystrophy - Very-low-fat diets may be beneficial for HIV-LD patients
HIV/AIDS RNA Research - Antiviral mechanisms of HIV exonic splicing silencers clarified
HIV/AIDS Therapy - Enzyme-linked minisequence HIV drug-resistance screen accurate, cost-effective
HIV/AIDS Therapy - HAART induces tolerogenic HLA-G expression by peripheral monocytes
HIV/AIDS Therapy - HCV coinfection delays CD4 cell recovery after HAART initiation
HIV/AIDS Therapy - Levels of anti-p24 IgG1 may mark HAART efficacy
HIV/AIDS Therapy - Web-based pager system modestly improves antiretroviral treatment adherence
Haemophilus Ducreyi - H. ducreyi cytolethal distending toxin can be blocked by CdtA-CdtC complex
Helicobacter Pylori - A complete H. pylori cag pathogenicity island confers greater disease
Helicobacter Pylori - Gastric mucosa reduces IL-4 when faced with Helicobacter pylori with cag
Immunology - L. pneumophila acts on a protein kinase, stops macrophage IL-12 production
Immunology - Albumin has innate immunity function, inhibits B. dermatitidis yeast growth
Immunology - Monoclonal antibody protects against S. aureus infections
Infectious Disease - H. ducreyi can give pustule or resolution regardless of phagocytosis level
Infectious Disease - Lyophilized S. cerevisiae responsible for ICU outbreak
Infectious Disease - Ocular toxoplasmosis can be treated to eliminate deterioration of vision
Influenza - Company reports positive laboratory-confirmed results from FluINsure vaccine
Kidney Disease - Understanding the role of complement in renal disease may lead to better therapy
Legionnaires Disease - Legionella pneumophila LvhB2 is involved in infectivity efficiency at 30 degrees C
Malaria Therapy - Reintroduction of standard malaria treatment in Vietnam qualified success
Mergers and Acquisitions - Health products company obtains rights to antimicrobial line of products
Otorhinolaryngology - Allergies and autoimmune disease can affect the ears
Patents - Company announces new patent for nanobacteria eradication and therapeutics
Plague - ID Biomedical announces additional contract related to a subunit plague vaccine
Pulmonary Medicine - Cardiac troponin I positivity may help predict pediatric RSV respiratory failure
Pulmonary Tuberculosis - Cutaneous tuberculosis rare in treated pulmonary TB patients
Quality Assurance - Practice parameters are being developed for managing pediatric allergy, asthma
Rickettsias - Anaplasma marginale varies membrane antigens; may explain disease cyclicity
Salmonella Enterica Typhi - Commensal bacterial products can increase invasion potential of S. enterica
Staphylococcus Aureus - Study: Battle MRSA bacteria in hospitals by flooding hospitals with viruses
Streptococcus Pneumoniae - S. pneumoniae virulence involves control of oxygen by the MicAB kinase
Transplant Medicine - Xylohypha bantiana can cause curable brain abscess similar to aspergillosis
Transplant Medicine - Polyomavirus nephropathy, tubulitis benefit most from lower immunosuppression
Tuberculosis Diagnostics - Colorimetric assay suitable for identification of drug-resistant TB strains
Tuberculosis Drug Resistance - High rate of fluoroquinolone resistance in new TB cases
Tuberculosis Drug Resistance - Mycobacterial katG, inhA mutations highly predictive of isoniazid resistance
Tuberculosis Therapy - Plasma pooling effective for finding rifampicin bioequivalence in FDCs
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