Published in Anti-Infectives Week, March 15th, 2004
"Mutations in Plasmodium falciparum dihydropteroate synthase have been linked to resistance to the antimalarial drug, sulfadoxine, which competes with the dihydropteroate synthase substrate, p-aminobenzoate," scientists in Australia explained.
"In an effort to evaluate the role of these mutations in a simple model system," J. Berglez and colleagues at the Commonwealth Scientific and Industrial Research Organization in Parkvill "expressed six relevant alleles of the P. falciparum dihydropteroate synthase gene in Escherichia coli."
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