Antimicrobials

New steroidal dimers are antifungal and inhibit human oral and breast cancer

Published in Anti-Infectives Week, April 26th, 2004

New steroidal dimers have antifungal properties and totally inhibit growth of human oral and breast cancers.

"Bile acid-derived novel amphiphilic topology was designed and synthesized in the form of steroidal dimers," wrote scientists in the Journal of Medicinal Chemistry.

"These dimers were tested for antifungal and antiproliferative activity in vitro. N-1,N-3-Diethylenetriaminebis[cholic acid amide] was found to be active against C. albicans, Y. lipolytica, and B. poitrassi at nanomolar concentration and did not show any effect on cell proliferation," reported D.B. Salunke and colleagues.

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Source: Anti-Infectives Week (2004-04-26)

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