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Anti-Infectives Week

Susan Hasty, Publisher

Table of Contents . . . May 3rd, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Anti-Infectives Week | Other Publications

Anti-Infectives - Suprax launched in the U.S.

Antimicrobials - Novel antibacterial agents for skin infections reviewed

Drug Resistance - Optimizing antibacterial therapy for respiratory infections described

Microbiology - Amoebae-resisting bacteria isolated from amoebal coculture

Pneumococcal Vaccine - Pneumococcal vaccine not useful in HIV patients responding to HAART

Tuberculosis Diagnostics - Varible Etest TB drug resistance results cause concern

Antibiotics - AACR data indicate strong synergy of Hsp90 inhibitor, 17-AAG

Antifungal Agents - CLEAR II registry launched

Antimicrobial Drug Resistance -  Plasmodium falciparum drug resistance in India determined

Bacterial Vaginosis - Microbes that produce hydrogen peroxide reduce obstetrical complications

Business & Finance - PhotoPoint company reports progress during 2003, including lower net loss

Cancer Therapy - Studies support Targretin's activity in NSCLC

Cancer Vaccine - P-glycoprotein-derived peptides inhibited multidrug resistance of tumors

Decontamination - Italian government places $1.1 million initial order for SR-1

Dermatology - SkinRenu Plus maker announces worldwide launch of its products

Drug Development -  Plasmodium vivax vivapains characterized

Drug Development - Novel assay provides improved measure of plasmodial Plm II activity

Drug Development - Novel ribonuclease has antimicrobial and antiproliferative activities

Drug Development - Novel sesquiterpene lactones show promise as antimalarial agents

Drug Development - Pyrrole BM212 derivatives have improved antimycobacterial activity

Drug Development - QSAR analysis on anti-HIV HEPT analogues described

Drug Resistance - Pyrrolopyrimidine a novel and selective MRP1 inhibitor

Epidemiology - Multilocus sequence Staphylococcus epidermidis typing effective

HIV/AIDS Gene Therapy - Recombinant AAV-2 useful as anti-HIV RNAi vector

HIV/AIDS Immune Control - HAART-induced recovery of HIV-specific immunity described

HIV/AIDS Opportunistic Infection - Dapsone-induced hypersensitivity pneumonitis can mimic PCP

HIV/AIDS Opportunistic Infection - Essential eukaryotic core identified from P. carinii

HIV/AIDS Opportunistic Infection - Visceral leishmaniasis relapse common during ineffective HAART

HIV/AIDS Therapy - Antiretroviral therapy does not prevent contingent negative variation

HIV/AIDS Therapy - Cessation of CMV retinitis therapy has no long-term sequelae for HIV patients

HIV/AIDS Therapy - Dose escalation unnecessary in patients switching to nevirapine from efavirenz

HIV/AIDS Therapy - Early IL-2 treatment increases CD4 cell count in HIV patients

HIV/AIDS Therapy - In utero AZT exposure has little or no impact on neurodevelopment

HIV/AIDS Therapy - Indinavir superior to ritonavir and saquinavir in triple therapies

HIV/AIDS Therapy - Indinavir/ritonavir/efavirenz regimen should benefit treatment-naive patients

HIV/AIDS Therapy - Pre-HAART IL-7 levels linked to long-term CD4 cell count

HIV/AIDS Therapy - Surgery can benefit patients with antiretroviral-induced "buffalo hump"

Hospital Pathogens - Antimicrobial technology granted EPA registration

Hospitalization - More hospitals offering private rooms and reducing nosocomial infection

Microbiology - Nonculturable bacteria thrive in the human urinary tract

Nosocomial Infection - Handrub promotion extremely cost-effective

Oncogenesis - Oncogenesis from single base mutation in IRES of Epstein-Barr nuclear antigen 1

Parasitology - Preventive practices eliminate the risk for congenital toxoplasmosis

Patents - U.S. patent filed for anti-sepsis compound

Periodontitis - Patient enrollment begins for phase III study of PeriostatMR

Personnel - Detlef Albrecht, MD, named chief medical officer of biopharma company

Proteomics - Up-regulation of ubiquitin-specific protease enhances EBV proliferation in vitro

Retrovirology - Nedd 4 or ubiquitin ligase Nedd4 regulates human T-cell leukemia virus type 1

Tuberculosis Diagnostics - Broth microdilution with 7H9 broth suitable as TB drug resistance test

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