Proteomics

IDO degraded by the proteasome and NO has an effect on IDO protein stability

Published in Anti-Infectives Week, July 5th, 2004

IDO is degraded by the proteasome and nitric oxide has an effect on IDO protein stability.

"Tryptophan depletion resulting from indoleamine 2,3-dioxygenase (IDO) activity within the kynurenine pathway is one of the most prominent gamma interferon (IFN-gamma) -inducible antimicrobial effector mechanisms in human cells. On the other hand, nitric oxide (NO) produced by the inducible isoform of NO synthase (iNOS) serves a more immunoregulatory role in human cells and thereby interacts with tryptophan depletion in a number of ways," wrote scientists in Germany.

"We investigated the effects of NO on IDO gene transcription, protein synthesis, and enzyme...

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Source: Anti-Infectives Week (2004-07-05)

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