Drug Delivery
Microencapsulation improves safety and efficacy of amphotericin B
Published in Anti-Infectives Week, November 1st, 2004
In a recent study from Spain, "[h]ydrophilic albumin microspheres" were evaluated for use as "a new delivery system" for AMB.
"The acute toxicity of AMB microspheres was lower than that of the AMB-deoxycholate (AMB-Doc) reference formulation in hamsters," J.A. Sanchez-Brunete and coauthors at the University of Complutense found. "Lethal doses in healthy and infected animals were improved at least eight times."
"Intravenous bolus administration of doses of AMB microspheres up to 40 mg/kg of body weight did not produce acute symptoms of toxicity," test...
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Source: Anti-Infectives Week (2004-11-01)
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