HIV/AIDS Research
Antisense U7 snRNAs and siRNAs targeting cyclophilin A inhibit HIV-1 replication
Published in Anti-Infectives Week, November 1st, 2004
According to published research from Switzerland, "Human immunodeficiency virus 1 (HIV-1) multiplication depends on a cellular protein, cyclophilin A (CyPA), that gets integrated into viral particles. Because CyPA is not required for cell viability, we attempted to block its synthesis in order to inhibit HIV-1 replication."
"For this purpose, we used antisense U7 small nuclear RNAs (snRNAs) that disturb CyPA pre-mRNA splicing and short interfering RNAs (siRNAs) that target CyPA mRNA for degradation," wrote S.K. Liu and coworkers.
"With...
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Source: Anti-Infectives Week (2004-11-01)
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